Journal article
Alyssa Kriegermeier, Angela Hyon, Meredith A. Sommars, S. Hubchak, Brian E. LeCuyer, Xiaoying Liu, G. Barish, R. Green
Hepatology, 2021
Hepatology, 2021
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APA
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Kriegermeier, A., Hyon, A., Sommars, M. A., Hubchak, S., LeCuyer, B. E., Liu, X., … Green, R. (2021). Hepatic X‐Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury. Hepatology.
Chicago/Turabian
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Kriegermeier, Alyssa, Angela Hyon, Meredith A. Sommars, S. Hubchak, Brian E. LeCuyer, Xiaoying Liu, G. Barish, and R. Green. “Hepatic X‐Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury.” Hepatology (2021).
MLA
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Kriegermeier, Alyssa, et al. “Hepatic X‐Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury.” Hepatology, 2021.
BibTeX Click to copy
@article{alyssa2021a,
title = {Hepatic X‐Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury},
year = {2021},
journal = {Hepatology},
author = {Kriegermeier, Alyssa and Hyon, Angela and Sommars, Meredith A. and Hubchak, S. and LeCuyer, Brian E. and Liu, Xiaoying and Barish, G. and Green, R.}
}
Abstract
The unfolded protein response (UPR) is a coordinated cellular response to endoplasmic reticulum (ER) stress that functions to maintain cellular homeostasis. When ER stress is unresolved, the UPR can trigger apoptosis. Pathways within the UPR influence bile acid metabolism in adult animal models and adult human liver diseases, however, the UPR has not been studied in young animal models or pediatric liver diseases. In this study we sought to determine whether weanling age mice had altered UPR activation compared with adult mice, which could lead to increased bile acid–induced hepatic injury.